Tadarise 40 mg is a medication used to treat erectile dysfunction (ED) that contains tadalafil, a type of phosphodiesterase type 5 (PDE5) inhibitor. Here's how it works:

Inhibition of PDE5: Tadalafil works by inhibiting the enzyme PDE5, which normally breaks down cyclic guanosine monophosphate (cGMP). cGMP plays a crucial role in relaxing the smooth muscles in the blood vessels of the penis, allowing them to expand and increase blood flow.

Increased Blood Flow: By preventing the breakdown of cGMP, tadalafil allows for more relaxation of the blood vessels in the penis, increasing blood flow. This helps to produce and maintain an erection when sexually stimulated.

Timing and Duration: Tadarise 40 mg has a longer duration of action compared to some other ED medications, often working for up to 36 hours, which is why it's often called the "weekend pill." It doesn’t cause an erection without sexual stimulation, as the effect is dependent on arousal.

It’s important to take Tadarise as prescribed, typically about 30 minutes before sexual activity, and to avoid certain medications or excessive alcohol use, which can interfere with its effectiveness.